Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue.
Authors Peterson KR, Flaherty DK, Hasty AH
Submitted By Submitted Externally on 11/9/2017
Status Published
Journal Obesity (Silver Spring, Md.)
Year 2017
Date Published 11/1/2017
Volume : Pages 25 : 1881 - 1884
PubMed Reference 28922564
Abstract The prevalence of obesity continues to rise, and it is understood that
regulation of white adipose tissue (WAT) function is important to systemic
metabolic homeostasis. Immune cells play a central role in the maintenance of
WAT, and their compositions change in number and inflammatory phenotype with the
progression of obesity. Because of its energy-burning capabilities, brown
adipose tissue (BAT) has become a focus of obesity research. Although novel
studies have focused on the function of brown adipocytes in thermogenesis, the
tissue as a whole has not been immunologically characterized., BAT immune cell
populations were analyzed by flow cytometry and immunohistochemistry in mice
with diet-induced obesity (3, 8, or 16 weeks of diet) and in aged mice (1, 6-7,
and 10-15 months)., The data confirmed the presence of macrophages and
eosinophils, as previously reported, and showed that 20% to 30% of the immune
cells in BAT were B cells. The number of B cells and eosinophils increased with
diet-induced obesity, whereas macrophages decreased. There was no change in
number of any immune cell quantified with age., These studies reveal a novel
finding of B220?+?B cells in BAT and show that BAT immune cell populations
change in response to diet-induced obesity.