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University of Massachusetts Medical School

Description Tests for insulin resistance, glucose metabolism, insulin secretion, energy
balance, obesity, and serum/tissue factors of diabetes.
Director / Email Jason Kim, Ph.D. -
General Contact
Grant Number DK093000
RRID SCR_015366 (Cite This)

Center Cores:

 Center CoreCore DescriptionRRID

Center: University of Massachusetts Medical School; Director: Jason Kim, Ph.D.

 Metabolism CoreThe Metabolism Core performs elegant and non-invasive metabolic experiments to assess insulin sensitivity, glucose/lipid/protein metabolism, body composition and energy balance in conscious mice.SCR_015369
 Analytical CoreThe Analytical Core utilizes clinical chemistry analyzer and Luminex to perform high-throughput measurement of serum/tissue hormones, metabolites and cytokines known to affect metabolismSCR_015365
 Animal Care CoreThe Animal Care Core provides services and facilities for stable, biocontainment housing, husbandry, and health care of mice. The Core manages transfer of mice from the user's institution and testing of mice for the quarantine process.SCR_015368
 Islet CoreThe Islet Core provides comprehensive in vivo, ex vivo, and in vitro analysis of pancreatic function and islet structure. The Core services enhance whole body metabolic characterization given the interrelatedness of insulin action and insulin secretion, while altered islet function and mass play an important role in the onset of diabetes phenotypes (hyperglycemia).SCR_015370
 Cardiovascular CoreThe Cardiovascular Core provides state-of-the-art phenotyping of cardiovascular system in mouse models of metabolic disease and an easily accessible cardiovascular disease model pipeline. The Core services enhance whole body metabolic characterization given that cardiovascular complications represent the major source of morbidity and mortality in obesity and diabetes.SCR_015375
 Humanized MouseThe Humanized Mouse Cell Transplantation and Assessment Core provides “humanized” mice that enable clinically relevant in vivo studies of human cells, tissues, and immune system without putting patients at risk. Humanized mice are immunodeficient mice engrafted with functional human cells and tissues and importantly address the scientific gap between human and mouse biologySCR_015372
 Microbiome CoreThe human gut microbiome consists of trillions of bacteria that have been shown to affect multiple organ systems including the brain, immune system, endocrine system, and metabolism, and may play an important role in the pathogenesis of major human diseases including type 2 diabetes. Our new Microbiome Core is directed by Dr. Beth McCormick (Professor and Vice Chair of Microbiology and Physiological Systems), who is a leading scientist in microbiome research, and provides expert knowledge and state-of-the-art tools for researchers to study gut microbiota in mouse models of human diseases to advance our understanding of this critical interplay. The Microbiome Core offers: • Consultation service for the design and implementation of gut microbiome studies • Sample preparation and quality control tests • Metagenomic 16S rRNA NextGen sequencing methodologies • Post-sequencing consultation for data analysis, interpretation, upload, and presentation • Fecal Microbiota Transplant (FMT) procedure to selectively alter gut microbiota in mice • Chronic and acute antibiotic treatment to induce altered gut microbiota in mice 


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