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Experiment

Metabolic Cage Study in HFD-fed Adiponectin-Raptor KO Mice
Summary Data Summary
Investigator Guertin, David
Description Adiponectin-Cre expressing Raptor (mTORc) KO mice - adipose tissue does not grow
in response to HFD, liver accumulates greater lipids than control, insulin
resistance.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 12/10/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainMetadataExperiment Description
Data Analysis
TypeCount
Animals12
Experimental Conditions2
Catalog Items2
Curation Info (# flags)3
Phenotype Assays9
Phenotype Measurements108
Histology Images0
Publications0
Phenotypes9


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
6
0
C57BL/6-Rptortm1Lex Tg(Adipoq-cre)1Evdr
0
6
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D12492i
Irradiated form of D12492, Rodent Diet with 60% kcal% fat.



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0003960increased lean body mass
greater amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0004890decreased energy expenditure
decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten [MGI:smb]
MMPC Search Results
MP:0005290decreased oxygen consumption
less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body [MESH:G06.535.723]
MMPC Search Results
MP:0008964decreased carbon dioxide production
reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010025decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0010378increased respiratory quotient
increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0011939increased food intake
increase in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0014143decreased body fat mass
decreased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results

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