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New comment to be added:
Exercise-Treadmill Study in C57BL/6 Mice After Treatment with
7,8-Dihydroxyflavone in Drinking Water
The animals are used to test the effect of 7,8-Dihydroxyflavone on skeletal
muscle activity. The mice would have better exercise (endurance) performance
compared to controls not given 7,8-Dihydroxyflavone in their water.
Applicable research area(s): Metabolism
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Drug Administered
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ˜ 320...
No Drug or Treatment done on these samples
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
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Mammalian Phenotype (MP) Terms
enhanced exercise endurance
improved performance during controlled physical activity [MGI:smb]
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
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