mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Experiment

Analytical Study in Gli2 and Shh Heterozygous KO Mice
Summary Data Summary
Investigator Muenke, Maximilian
Description B6-Gli2tmMat and B6-ShhtmChia
We are using Gli2 and Shh heterozygous knockout strain as a model of fatty liver
disease. It is our hypothesis that mutations in the Shh pathway predispose to
fatty liver in the general population. Mutant and wild-type mice were exposed to
control of high-fat diet for 12, 24 and 32 weeks. Endpoint evaluations included
weight gain, body composition EchoMRI, liver ultrasound and ex vivo liver MRI
spectroscopy. Also blood and liver tissue were collected for complete metabolic
and histological examination.

Applicable research area(s): Metabolism
Status Completed
Public Release 12/10/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals139
Experimental Conditions1
Catalog Items11
Curation Info (# flags)1
Phenotype Assays11
Phenotype Measurements1529
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
0
55
0
C57BL/6-Gli2tm1Mat/+
0
39
0
C57BL/6-Shhtm1Chg/+
0
45
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.