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Experiment

Analytical Study in Gli2 Heterozygous KO Mice
Summary Data Summary
Investigator Muenke, Maximilian
Description We are using these Gli2 heterozygous knockout strain as a model of fatty liver
disease. It is our hypothesis that mutations in the Shh pathway predispose to
fatty liver in the general population. Mutant and wild-type mice were exposed to
control of high-fat diet for 12 weeks. Endpoint evaluations included weight
gain, body composition EchoMRI, liver ultrasound and ex vivo liver MRI
spectroscopy. Also blood and liver tissue were collected for complete metabolic
and histological examination.

This study will be led by Dr. Randall Friedline and Xiaodi Hu.

Applicable research area(s): Metabolism
Status Completed
Public Release 12/11/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainExperiment Description
Data Analysis
TypeCount
Animals25
Experimental Conditions1
Catalog Items13
Curation Info (# flags)2
Phenotype Assays12
Phenotype Measurements300
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
0
11
0
C57BL/6-Gli2tm1Mat/+
0
14
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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