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New comment to be added:
Analytical Study in Gli2 Heterozygous KO Mice
We are using these Gli2 heterozygous knockout strain as a model of fatty liver
disease. It is our hypothesis that mutations in the Shh pathway predispose to
fatty liver in the general population. Mutant and wild-type mice were exposed to
control of high-fat diet for 12 weeks. Endpoint evaluations included weight
gain, body composition EchoMRI, liver ultrasound and ex vivo liver MRI
spectroscopy. Also blood and liver tissue were collected for complete metabolic
and histological examination.
This study will be led by Dr. Randall Friedline and Xiaodi Hu.
Applicable research area(s): Metabolism
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
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urea nitrogen, blood
non-esterified free fatty acids
cholesterol, HDL (COBAS)
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Mammalian Phenotype (MP) Terms
increased circulating serum albumin level
blood serum albumin concentration above the normal range [RGD:cur]
MMPC Search Results
increased circulating creatinine level
greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction [ISBN:0-683-40008-8| RGD:cur]
MMPC Search Results
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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