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Experiment

Metabolic Clamp Study in Adipose-Specific Deletion of Insulin Receptor, IGF-1R,
and FOXO1/3/4
Summary Data Summary
Investigator Kahn, C. Ronald
Description This study involves 26 mice (7 F-IGIR KO mice, 8 F-Quint KO mice, 6 Quint
controls, and 5 IGIR-floxed controls) for body composition analysis and
hyperinsulinemic-euglycemic clamp study.

F-IGIR KO: Adipose-specific IGF-1R/IR KO mice; F-Quint KO: Adipose-specific
IGF-1R/IR/Foxo1/3/4 KO mice

Applicable research area(s): Diabetes, Metabolism, Obesity
Status Completed
Public Release 3/20/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountNomenclature
Data Analysis
TypeCount
Animals23
Experimental Conditions1
Catalog Items4
Curation Info (# flags)3
Phenotype Assays14
Phenotype Measurements322
Histology Images0
Publications0
Phenotypes7


Animals

Strain NameCommon NameFemalesMalesUnknown
Adiponectin-cre Igf1r/Insr DKO
0
6
0
Igf1r fl/fl; Insr fl/fl
0
5
0
Adiponectin-cre Igf1r/Insr/Foxo1/Foxo3/Foxo4 Quint KO
0
8
0
Igf1r fl/fl; Insr fl/fl; Foxo1 fl/fl; Foxo3 fl/fl; Foxo4 fl/fl
0
4
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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