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Experiment

Metabolic Clamp Study in Liver-Specific Ceacam1 KO Mice
Summary Data Summary
Investigator Najjar, Sonia
Description Liver-specific inactivation and global null mutation of Ceacam1 cause systemic
insulin resistance in addition to all clinical and biochemical features of
fibrosing steatohepatitis (macrosteatosis, inflammation, apoptosis, necrosis and
chicken-wire fibrosis) that progress to NASH in response to inflammatory cues
elicited by a sustained high fat intake. Moreover, global Ceacam1 deletion
generates a pro-inflammatory state, typically detected in NASH patients,
including a Th1 inflammatory phenotype and neutrophilia. Thus, Ceacam1 mutant
mice are indisputably reliable replicates of the human disease and provide a
valuable tool to understand the molecular underpinning of NASH. The importance
of our findings is highlighted by the recent report demonstrating a marked
decrease of CEACAM1 levels in the liver of obese subjects with fatty liver
disease, independently of diabetes

Applicable research areas: Cardiovascular, Diabetes, Metabolism, Obesity
Status Completed
Public Release 3/22/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal CountNo Experimental GroupExperiment Description
Data Analysis
TypeCount
Animals22
Experimental Conditions1
Catalog Items7
Curation Info (# flags)3
Phenotype Assays15
Phenotype Measurements308
Histology Images0
Publications0
Phenotypes1


Animals

Strain NameCommon NameFemalesMalesUnknown
Ceacam1fl
0
12
0
C57BL/6-Ceacam1tm1Rsb Tg(Alb-Cre)
0
10
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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