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Experiment

Metabolic Study in Lyz-JNK1/2 DKO Mice
Summary Data Summary
Investigator Davis, Roger J.
Description I would like to examine clamp study on macrophage specific JNK1/2 DKO (LYAB)
mice after 16wks HFD. I want to send Normal diet and HFD group before 16 wks
HFD(10/28/11).

This study is approved for the Metabolism Core of MMPC and will involve 19 WT
and 18 LYZ-JNK1/2 DKO mice on chow and 16-wk HFD for body composition and
hyperinsulinemic-euglycemic clamps.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 5/2/2015
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals33
Experimental Conditions2
Catalog Items5
Curation Info (# flags)2
Phenotype Assays12
Phenotype Measurements363
Histology Images0
Publications0
Phenotypes1


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
18
0
Macrophage specific JNK1/2 DKO
0
15
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet 5P75/5P76
Prolab 5P75 and 5P76 Isopro 3000 are the irradiated forms of RMH 3000 (5P00). The product has been irradiated to virtually bacteria-free dietary control. Protien 22.5%, Fat 5.4% Cholesterol 195 ppm
 Teklad - 93075
Harlan-Teklad TD.93075 Adjusted Calorie diet (Calories: 21% protein, 55% Fat, 24% Carbohydrate) A diet used to induce obesity. Approximate fatty acid profile (% total fat): 28% saturated, 30% trans, 28% monounsaturated (cis), 14% polyunsaturated...



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