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Experiment

Metabolic Study in Rip-MKK4/7 DKO Mice
Summary Data Summary
Investigator Davis, Roger J.
Description This study is approved for the Metabolism Core of UMass MMPC and will involve 16
WT and 16 Rip-MKK4/7 KO mice that will be divided into n=8 for chow and HFD-fed
mice (n=8 for WT mice, n=8 for Rip-MKK4/7 KO mice, n=8 for WT-HFD Mice, and n=8
for Rip-MKK4/7 KO-HFD mice). This study will be led by Dae Young Jung. HFD will
begin on 11/21, and hyperinsulinemic-euglycemic clamps will be performed after 7
wks of HFD during the week of 1/9/12. Mice will remain in Davis room until
1/2/12 when they are transferred into LRB-124 for surgery.


Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 5/2/2015
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainAnimal CountExperiment Description
Data Analysis
TypeCount
Animals31
Experimental Conditions2
Catalog Items5
Curation Info (# flags)3
Phenotype Assays12
Phenotype Measurements372
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
16
0
Rip-MKK4/7 DKO
0
15
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet 5P75/5P76
Prolab 5P75 and 5P76 Isopro 3000 are the irradiated forms of RMH 3000 (5P00). The product has been irradiated to virtually bacteria-free dietary control. Protien 22.5%, Fat 5.4% Cholesterol 195 ppm
 Teklad - 93075
Harlan-Teklad TD.93075 Adjusted Calorie diet (Calories: 21% protein, 55% Fat, 24% Carbohydrate) A diet used to induce obesity. Approximate fatty acid profile (% total fat): 28% saturated, 30% trans, 28% monounsaturated (cis), 14% polyunsaturated...



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