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Experiment

Vsg / sham in Ppar alpha deficient males / NIU063111
Summary Data Summary
Investigator Sandoval, Darleen
Description lipid tolerance tests (LTT), mice were fasted 12 h and then IP injected with 20%
emulsified Intralipid
All on Research Diets D03082706

Ppara deficient mutant mice exhibit increased gonadal adipose tissue stores,
abnormal epidermal development and delayed wound healing. This mutant mouse
strain may be useful in studies of lipid metabolism, cell proliferation,
diabetes, obesity, and wound

Applicable research area(s): Diabetes, obesity
Status Completed
Public Release 2/12/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals32
Experimental Conditions3
Catalog Items1
Curation Info (# flags)2
Phenotype Assays4
Phenotype Measurements512
Histology Images0
Publications0
Phenotypes5


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
15
0
B6;129S4-Pparatm1Gonz
0
17
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Surgical Procedure

 Sham
Control Sham Procedure
 Vertical Sleeve Gastrectomy
Vertical Sleeve Gastrectomy

Experimental Factor: Time Postprandial (hr)

 time postprandial
Length of time since last food intake (meal)


No documents found.


Mammalian Phenotype (MP) Terms
MPTermIDMPTermNameDefinitionOther Results
MP:0001554increased circulating free fatty acids level
higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues [ISBN:0-683-40008-8]
MMPC Search Results
MP:0002644decreased circulating triglyceride level
reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue| commonly circulate in the blood in the form of lipoproteins| and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver [MGI:csmith]
MMPC Search Results
MP:0002702decreased circulating free fatty acids level
lower than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues [ISBN:0-683-40008-8]
MMPC Search Results
MP:0003981decreased circulating phospholipid level
reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group [MGI:smb| RGD:cur]
MMPC Search Results
MP:0005179decreased circulating cholesterol level
less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids| including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues [MGI:csmith]
MMPC Search Results

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