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Publication
The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource
for in vivo characterization of mouse models of diabetes and obesity.
Authors Laughlin M, McIndoe R, Adams SH, Araiza R, Ayala JE, Kennedy L, Lanoue L,
Lantier L, Macy J, Malabanan E, McGuinness OP, Perry R, Port D, Qi N, Elias CF,
Shulman GI, Wasserman DH, Lloyd KCK
Submitted By Submitted Externally on 10/15/2024
Status Published
Journal Mammalian genome : official journal of the International Mammalian Genome Society
Year 2024
Date Published 8/1/2024
Volume : Pages Not Specified : Not Specified
PubMed Reference 39191872
Abstract The Mouse Metabolic Phenotyping Center (MMPC)Live Program was established in
2023 by the National Institute for Diabetes, Digestive and Kidney Diseases
(NIDDK) at the National Institutes of Health (NIH) to advance biomedical
research by providing the scientific community with standardized, high quality
phenotyping services for mouse models of diabetes and obesity. Emerging as the
next iteration of the MMPC Program which served the biomedical research
community for 20 years (2001-2021), MMPCLive is designed as an outwardly-facing
consortium of service cores that collaborate to provide reduced-cost
consultation and metabolic, physiologic, and behavioral phenotyping tests on
live mice for U.S. biomedical researchers. Four MMPCLive Centers located at
universities around the country perform complex and often unique procedures in
vivo on a fee for service basis, typically on mice shipped from the client or
directly from a repository or vendor. Current areas of expertise include energy
balance and body composition, insulin action and secretion, whole body
carbohydrate and lipid metabolism, cardiovascular and renal function, food
intake and behavior, microbiome and xenometabolism, and metabolic pathway
kinetics. Additionally, an opportunity arose to reduce barriers to access and
expand the diversity of the biomedical research workforce by establishing the
VIBRANT Program. Directed at researchers historically underrepresented in the
biomedical sciences, VIBRANT-eligible investigators have access to testing
services, travel and career development awards, expert advice and experimental
design consultation, and short internships to learn test technologies. Data
derived from experiments run by the Centers belongs to the researchers
submitting mice for testing which can be made publicly available and accessible
from the MMPCLive database following publication. In addition to services,
MMPCLive staff provide expertise and advice to researchers, develop and refine
test protocols, engage in outreach activities, publish scientific and technical
papers, and conduct educational workshops and training sessions to aid
researchers in unraveling the heterogeneity of diabetes and obesity.




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