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Publication

Time-dependent changes in feeding behavior and energy balance associated with
weight gain in mice fed obesogenic diets.

Authors	Fathi PA, Bales MB, Ayala JE
Submitted By	Submitted Externally on 10/15/2024
Status	Published
Journal	Obesity (Silver Spring, Md.), References
Year	2024
Date Published	7/1/2024
Volume : Pages	32 : 1373 - 1388
PubMed Reference	38932722
Abstract	Obesity is characterized by dysregulated homeostatic mechanisms resulting in positive energy balance; however, when this dysregulation occurs is unknown. We assessed the time course of alterations to behaviors promoting weight gain in male and female mice switched to an obesogenic high-fat diet (HFD)., Male and female C57BL/6J mice were housed in metabolic chambers and were switched from chow to a 60% or 45% HFD for 4 and 3?weeks, respectively. Food intake, meal patterns, energy expenditure (EE), and body weight were continuously measured. A separate cohort of male mice was switched from chow to a 60% HFD and was given access to locked or unlocked running wheels., Switching mice to obesogenic diets promotes transient bouts of hyperphagia during the first 2?weeks followed by persistent caloric hyperphagia. EE increases but not sufficiently enough to offset increased caloric intake, resulting in a sustained net positive energy balance. Hyperphagia is associated with consumption of calorically larger meals (impaired satiation) more frequently (impaired satiety), particularly during the light cycle. Running wheel exercise delays weight gain in male mice fed a 60% HFD by enhancing satiation and increasing EE. However, exercise effects on satiation are no longer apparent after 2?weeks, coinciding with weight gain., Exposure to obesogenic diets engages homeostatic regulatory mechanisms for ~2?weeks that ultimately fail, and consequent weight gain is characterized by impaired satiation and satiety. Insights into the etiology of obesity can be obtained by investigating changes to satiation and satiety mechanisms during the initial ~2?weeks of HFD exposure.

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