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Non-visual arrestins regulate the focal adhesion formation via small GTPases
RhoA and Rac1 independently of GPCRs.
Cleghorn WM, Bulus N, Kook S, Gurevich VV, Zent R, Gurevich EV
Submitted Externally on 1/3/2018
Volume : Pages
42 : 259 - 269
Arrestins recruit a variety of signaling proteins to active phosphorylated G
protein-coupled receptors in the plasma membrane and to the cytoskeleton. Loss
of arrestins leads to decreased cell migration, altered cell shape, and an
increase in focal adhesions. Small GTPases of the Rho family are molecular
switches that regulate actin cytoskeleton and affect a variety of dynamic
cellular functions including cell migration and cell morphology. Here we show
that non-visual arrestins differentially regulate RhoA and Rac1 activity to
promote cell spreading via actin reorganization, and focal adhesion formation
via two distinct mechanisms. Arrestins regulate these small GTPases
independently of G-protein-coupled receptor activation.
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