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Exon 4 of the C1qtnf1 gene was replaced with an FRT-flanked
lacZ and neomycin resistance cassette.
Targeted or gene trap mutations are generated in strain
129/SvEvBrd-derived embryonic stem (ES) cells. The chimeric
mice are bred to C57BL/6-Tyrc-Brd albino mice albino mice to
generate F1 heterozygous animals. These progeny are
intercrossed to generate F2 wild type, heterozygous, and
homozygous mutant progeny. On rare occasions, for example
when very few F1 mice are obtained from the chimera, F1
heterozygous mice are crossed to 129/SvEvBrd x C57BL/6
hybrid mice to yield additional heterozygous animals for the
intercross to generate the F2 mice.
C1qtnf1 knockout mice, when fed a control low-fat diet,
develop insulin resistance and pronounced fatty liver as
compared to control wild type mice.
Genomics - Modifications
G. William Wong
Johns Hopkins University School of Medicine
Curation Flag Information
New comment to be added:
G. William Wong
Metabolic Clamp Study to Assess Insulin Sensitivity in CTRP1 KO Mice
Loss of CTRP1 disrupts glucose and lipid homeostasis.
Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW
American journal of physiology. Endocrinology and metabolism
, 2016 (311), E678 - E697
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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