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MMPC will provide the community with up-to-date information on new course availability. This page will be updated periodically with current course information.
Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis
Glucose Clamping The Conscious Mouse: A Laboratory Course
An Organ Systems Approach to Experimental Targeting of the Metabolic Syndrome
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Tracers in Metabolic Research
Annual Course on Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis
April 12 – 16, 2021
Homewood Suites by Hilton® Nashville Vanderbilt in Nashville, TN
Owen P. McGuinness, PhD, Elizabeth J. Parks, PhD
Sponsored by Mouse Metabolic Phenotyping Centers (MMPC)
This is the 12th annual offering of a course that provides basic introductory and comprehensive information on performing metabolic studies using tracers labeled with radioactive or stable isotopes, in man and in animals. The course is designed for beginners as well as those with experience who wish to expand their capabilities to more sophisticated problems. The faculty is well-versed in a variety of applications and methodologies.
Techniques will be presented for investigating whole body metabolism, for metabolite balance across organs, intracellular flux rates and pathway regulation. General aspects of modeling will be considered, as well as specific applications in the study of carbohydrate, fat, protein metabolism and energy balance. Theoretical and practical matters related to sample analysis by mass spectrometry and NMR will be discussed, including detailed numerical examples of calculations involved in determining isotopic enrichment and basic kinetic parameters. Advanced lectures will discuss in more detail the use of positional and mass isotopomer analysis for intracellular flux rates and various aspects of protein and amino acid metabolism. Applications in humans and animal models (particularly mouse) will be considered.
Course material will be presented in organized lectures and informal workshops. Problem sets and discussion questions will highlight each lecture. Lecture notes and problem sets will be available to registrants to be downloaded from the course website. In addition to organized sessions, attendees are encouraged to present their own projects and will have ample opportunities for personal interaction with faculty members to discuss issues of particular interest to them in depth.
Scholarships for graduate students and postdoctoral fellows to cover registration fees are available.
More information including the course syllabus, registration, and hotel information can be found at
If you have questions, please contact Eann Malabanan (
) or 615-343-1065).
You may also contact Maren Laughlin, Ph.D. at
or Owen McGuinness Ph.D. at
Registration Link (opens June 1st):
*Registration deadline: Oct. 1st
*Note: Register at your earliest convenience. This course typically reaches capacity (90 attendees) prior to registration deadline.
Download the 2019 Course Brochure
Download the 2019 Course Syllabus
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Glucose Clamping The Conscious Mouse
Due to the COVID-19, the 2020 course has been postponed until 2021
The Vanderbilt-NIDDK Mouse Metabolic Phenotyping Center (MMPC) presents the 16
semiannual course –
Glucose Clamping The Conscious Mouse:
A Laboratory Course
June 7-11, 2021 (Tentative)
Vanderbilt-NIDDK Mouse Metabolic Phenotyping Center
: Vanderbilt University
8455 Medical Research Building IV
A week-long course to familiarize participants with methods, protocols and quantitative tools necessary to perform glucose clamps in the conscious mouse.
: David Wasserman, PhD, Owen McGuinness, PhD, Julio Ayala, PhD, Louise Lantier, PhD
for more details.
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the MMPC using the following text:
Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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)'. To cite specific MMPC centers, please use the appropriate RRID available from the MMPC website (
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The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
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