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University of Michigan Medical School
http://mmpc.med.umich.edu

Description Tests for in vivo insulin sensitivity, lipid metabolism, automated blood
sampling, whole-body energy expenditure, and behavioral changes.
Director / Email Carol Elias - cfelias@med.umich.edu
General Contact mmpc-live@umich.edu
Grant Number DK135066
RRID SCR_015373 (Cite This)

Center Cores:

 Center CoreCore DescriptionRRIDInactive?

Center: University of Michigan Medical School; Director: Carol Elias

 Animal Care and Germ-Free CoreDirected by, Dr. Lucy Kennedy, The Animal Care and Germ-Free Core plays a central role in the management of animal flow through the Center’s phenotyping cores from initial acquisition to final disposition of imported mice. The gateway for all phenotyping involving live mice, the Animal Care and Germ-Free Mouse Core provides mouse importation, quarantine, housing, veterinary care, clinical chemistry and histopathology services; as well as, host a germ-free mouse facility that works to produce and distribute germ-free and gnotobiotic mouse models.SCR_015344Active
 Metabolic, Physiological and Behavioral Phenotyping CoreThe Metabolic, Physiological and Behavioral Phenotyping Core (also referred to as the Animal Phenotyping Core) is directed by Dr. Nathan Qi and performs a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic-euglycemic, hypo- or hyperglycemic clamps), lipid metabolism (3H-triolein lipid tolerance, 3H-palmitate FA fluxes) energy homeostasis (indirect calorimetry by CLAMS, Promethion systems with ambient temperature or dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from free moving, unrestrained mice), behavioral measurements (learning/memory, locomotor activity, anxiety, depression, meal pattern analysis, operant conditioning). Active

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