University of California Davis
University of Cincinnati Medical Center
University of Massachusetts Medical School
University of Michigan Medical School
Vanderbilt University School of Medicine
Protocols & Methods
Reagents & Resources
Tissues & Samples
Conditions of Use
Energy Expenditure Analysis
Guidelines & Policies
University of Michigan Medical School
Director / Email
Malcolm Low, Ph.D. -
Center: University of Michigan Medical School; Director: Malcolm Low, Ph.D.
Animal Care and Germ-Free Mouse Core
The Animal Care and Germ-Free Mouse Core plays a central role in the management of animal flow through the Center’s phenotyping cores from initial acquisition to final disposition of imported mice. The gateway for all phenotyping involving live mice, the Animal Care and Germ-Free Mouse Core provides mouse importation, quarantine, housing, veterinary care, clinical chemistry and histopathology services; as well as, host a germ-free mouse facility that will interact with the Microbiome core to produce and distribute germ-free and gnotobiotic mouse models.
Metabolism, Bariatric Surgery and Behavior Core
The primary goals and function of the Metabolism, Bariatric Surgery and Behavior Core are to provide expert consultation, state-of-the art equipment and technical services that are critical for the detailed metabolic and behavioral phenotyping of mouse models of diabetes, obesity and associated disorders. The Metabolism, Bariatric Surgery and Behavior Core will perform a variety of in vivo physiological assessments encompassing glucose homeostasis (glucose tolerance, insulin tolerance, hyperinsulinemic/euglycemic clamps), energy homeostasis (indirect calorimetry by CLAMS, dietary challenge), ultradian hormone secretion (Culex platform for serial biological fluid sampling from unrestrained mice), behavioral measurements (locomotor activity, meal pattern analysis, operant conditioning) and generation of bariatric surgery models.
Microvascular Complications Core
Provide a complete range of microvascular phenotyping of murine models of diabetes, obesity and metabolic disease; including validated, reproducible and standardized phenotyping of the 3 major microvascular complications: diabetic polyneuropathy (DPN), nephropathy (DN) and retinopathy (DR). DPN advanced testing will include phenotyping of models exhibiting neuropathy such as measures of cell death and oxidative stress in dorsal root ganglion (DRG) and peripheral nerve. DN advanced phenotyping will include measures of podocyte number, precise morphometric analysis of glomerular expansion, glomerular volume and tubulointerstitial fibrosis, EM morphometry of podocyte foot processes, immunohistochemical analysis of podocyte specific proteins, and glomerular isolation. DR advanced testing will include measures of retinal vascular permeability, retinal cell death and non-lethal measures of retinal morphology using optical coherence tomography and visual function using optokinetic response.
The goal of the Microbiome Core is to serve the specific needs of investigators who are studying the role that complex microbial communities can play in shaping the overall metabolic state of their host. Provide analytical tools to investigators to permit determination of the structure of the microbiome in mouse models of disease and assistance in the cultivation of microbes that will permit hypothesis testing in murine models including the germfree animals that are available in the Animal Care Core.
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The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
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