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Catalog Item
Acute arterial blood pressure (via arterial catheter)
Common Name(s): Blood pressure measurements

CenterVanderbilt University School of Medicine
Center CoreBody Weight Regulation Core
Test No.V3033
Test Price$138
DescriptionBlood pressure (BP) represents an integrated measure of overall cardiovascular
function, and is affected by stroke volume, heart rate, inotropic state, and
vascular tone. Abnormalities of BP regulation (primarily hypertension, but also
hypotension) are associated with major cardiovascular morbidity and mortality,
and are epidemiologically associated with diabetes and obesity.
Three complementary technologies are available for the measurement of BP: 1)
non-invasive tail-cuff plethysmography, 2) direct arterial measurement by
intracarotid catheterization, and 3) telemetry via implanted catheter.

(1) Tail-cuff Plethysmography. Plethysmography (tail-cuff) is performed using a
tail-cuff BP apparatus (BP-2000, Visitech Systems, Inc.). This technology is
non-invasive and there is good concordance with the direct BP measurements
described below.

(2) Carotid Catheterization. Direct arterial measurements are obtained via a
chronically placed catheter in the carotid artery. The catheter is connected to
a TXD-310 transducer and BP measured using a Digi-Med BPA 400 (Micromed).
Experiments using this approach are typically coordinated with metabolic
measurements.

A dual catheter approach (arterial and venous) allows for BP measurements in
response to specific pharmacological infusions in the awake or anesthetized
state; and enables evaluation of both peripheral and central mechanisms of BP
regulation.

(3) Telemetry. Telemetered direct BP measurement is performed using an implanted
micro-miniature device (PA-C10, DSI) implanted subcutaneously with the catheter
typically placed in the right carotid artery. The mouse is housed individually
in a cage placed over the receiver platform and BP data digitally recorded via
the DATAquest A.R.T. system (DSI). Advantages of this approach include the
ability to continuously record BP over a period of weeks, to assess the diurnal
range in BP, and stress artifact induced by animal handling is avoided.
DataData will be collected for this catalog item
Keywordsblood pressure, blood vessel, cardiac function, circulation, hypertension,
hypotension, vascular, vascular function
Tissuesaorta, heart



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