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Center Core
Animal Care, Surgery, and Pathology Core

Center University of California Davis
Description The Core provides extensive scientific support services, including
importation/exportation, colony management, customized mouse models,
rederivation and creation of genetically-modified mutant mice (e.g. CRISPR), and
re-animation of a variety of models cryopreserved within the KOMP or MMRRC
repositories. These new and extant mouse models can then be bred to produce male
and female cohorts for in vivo and in vitro phenotyping, including rederivation
into our Gnotobiotic Mouse Research Center for gut microbiome studies.

The Core also operates a Microsurgery Suite, with two expert microsurgeons, for
development of surgically-manipulated mouse models, such as bariatric surgical
models, e.g. Vertical Sleeve Gastrectomy (VSG) and Roux en Y Gastric Bypass
(RYGB), as well as cannulation telemetry and osmotic pump implants, in addition
to providing microsurgery training services for investigators and clinicians. In
addition to testing, manipulation, and sampling, investigator can have these
surgically-manipulated models as well as any genetically-engineered mouse lines
shipped from our approved vendor barrier vivarium directly into the recipient
institution’s vivarium.

The Core also provides ancillary services and procedures, including blood
sampling for in vivo testing for glucose tolerance tests and insulin tolerance
tests. We provide pathology analysis to complement other testing including
survey necropsy with histology, clinical chemistry and hematology analysis. This
testing can be customized to include specific organ histologic examination,
grading and photo documentation.

The Core is led by Kristin Grimsrud DVM, PhD, who oversees two trained rodent
surgical technicians, one import/export coordinator, and two phenotyping
technicians, and is co-led by Stephen Griffey DVM, PhD.
Center Core RRID SCR_015356 (Link)

Stephen GriffeyUniversity of California - Davissmgriffey@ucdavis.eduCo-Director
Kristin GrimsrudUniversity of California Daviskngrimsrud@ucdavis.eduDirector


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