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Center Core
Microvascular Complications Core

Center University of Michigan Medical School
Website https://mmpc.med.umich.edu/cores/microvascular-complications-core
Description Provide a complete range of microvascular phenotyping of murine models of
diabetes, obesity and metabolic disease; including validated, reproducible and
standardized phenotyping of the 3 major microvascular complications: diabetic
polyneuropathy (DPN), nephropathy (DN) and retinopathy (DR).

DPN advanced testing will include phenotyping of models exhibiting neuropathy
such as measures of cell death and oxidative stress in dorsal root ganglion
(DRG) and peripheral nerve.

DN advanced phenotyping will include measures of podocyte number, precise
morphometric analysis of glomerular expansion, glomerular volume and
tubulointerstitial fibrosis, EM morphometry of podocyte foot processes,
immunohistochemical analysis of podocyte specific proteins, and glomerular
isolation.

DR advanced testing will include measures of retinal vascular permeability,
retinal cell death and non-lethal measures of retinal morphology using optical
coherence tomography and visual function using optokinetic response.
Center Core RRID SCR_015376 (Link)

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