University of California Davis
University of Michigan Medical School
Vanderbilt University School of Medicine
Yale University School of Medicine
Protocols & Methods
Reagents & Resources
Tissues & Samples
Conditions of Use
Data Usage Policy
Tracers in Metabolic Research
Isotope Tracers in Metabolic Research: 3-Part Webinar Series
Energy Expenditure Analysis
CalR: Indirect Calorimetry Analysis
Guidelines & Policies
Microvascular Complications Core
University of Michigan Medical School
Provide a complete range of microvascular phenotyping of murine models of
diabetes, obesity and metabolic disease; including validated, reproducible and
standardized phenotyping of the 3 major microvascular complications: diabetic
polyneuropathy (DPN), nephropathy (DN) and retinopathy (DR).
DPN advanced testing will include phenotyping of models exhibiting neuropathy
such as measures of cell death and oxidative stress in dorsal root ganglion
(DRG) and peripheral nerve.
DN advanced phenotyping will include measures of podocyte number, precise
morphometric analysis of glomerular expansion, glomerular volume and
tubulointerstitial fibrosis, EM morphometry of podocyte foot processes,
immunohistochemical analysis of podocyte specific proteins, and glomerular
DR advanced testing will include measures of retinal vascular permeability,
retinal cell death and non-lethal measures of retinal morphology using optical
coherence tomography and visual function using optokinetic response.
Center Core RRID
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the MMPC using the following text:
Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.
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