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Experiment

Metabolic Study in GDF11-Treated Young and Old Male C57BL/6 Mice Fed High-fat
Diet
Summary Data Summary
Investigator Lee, Richard
Description Aging is associated with declined metabolic function. Interventions which
improve metabolic function in aged individuals have great therapeutic potential.
We would like to determine whether treatment to restore youthful circulating
levels of a protein that has been shown to decline with age can have durable
improvements in metabolic function in both young and old mice. These studies
will demonstrate the therapeutic potential of this treatment in aged
individuals.

This study is approved for the Metabolism Core of UMass MMPC and will involve 50
HFD-fed C57BL/6J mice for drug treatment (GDF-11 = vehicle), body composition,
and hyperinsulinemic-euglycemic clamp.

Male C57BL/6J mice from JAX will be ordered by Dr. Lee and sent to the UMass
MMPC. There will be 20 mice at 8 weeks of age and 30 mice at 24 months of age at
the time of arrival at UMass MMPC. Following arrival, mice will receive a HFD
and a daily treatment (ip injection) with saline or GDF-11 for 7 days prior to
the clamp experiment.

This study will be led by Dr. Hye-Lim Noh and Dr. Taekyoon Kim.

Applicable research area(s): Metabolism
Status Completed
Public Release 12/11/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountExperiment Description
Data Analysis
TypeCount
Animals36
Experimental Conditions2
Catalog Items5
Curation Info (# flags)3
Phenotype Assays13
Phenotype Measurements460
Histology Images0
Publications0
Phenotypes3


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
36
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 GDF-11
Growth Differentiation Factor 11 - This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family t
 Saline
Saline

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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