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Experiment

Effect of conditionally targeted (Sim1-cre or SF1-cre) knockout of Rai1 on
energy expenditure and meal patterns
Summary Data Summary
Investigator Luo, Liqun
Description Study the mouse model of Smith-Magenis syndrome

Effect of conditionally targeted (Sim1-cre or SF1-cre) knockout of Rai1 on
energy expenditure and meal patterns.

Applicable research area(s): Neurobiology, Metabolism
Status Completed
Public Release 3/25/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagMetadataExperiment Description
Data Analysis
TypeCount
Animals24
Experimental Conditions1
Catalog Items9
Curation Info (# flags)2
Phenotype Assays50
Phenotype Measurements1200
Histology Images0
Publications0
Phenotypes17


Animals

Strain NameCommon NameFemalesMalesUnknown
B6;129-Rai1tm1Luo Tg(Sim1-cre)1Lowl
8
0
0
B6;129-Rai1tm1Luo Tg(SF1-cre)7Lowl
8
0
0
B6.129-Rai1tm1Luo
8
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.


Phenotype Assays Add / Edit

NameAbbreviation
body mass
W rodent
oxygen consumption (Light Period)
VO2-L
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
RER-L
bone mineral density
BMD
bone mineral content
BMC
bone area
bone area
fat tissue, %
% body fat
heat (Light Period)
HEAT-Light
oxygen consumption (Dark Period)
VO2-D
carbon dioxide production Light Period
VCO2-L
carbon dioxide production Dark Period
VCO2-D
respiratory exchange ratio (Dark Period)
RER-D
heat (Dark Period)
HEAT-Dark
carbon dioxide production
VCO2
heat
HEAT
oxygen consumption
VO2
respiratory exchange ratio
RQ
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
tissue area
tissue area
total tissue mass
TTM
heat (24hr)
heat - 24h
meal duration (Avg) - Active Eating Time
avg meal dur AET
meal size (Avg)
avg meal size
meals, number
num meals
inter-meal interval, average
avg IMI
meal duration (total)
total meal duration
satiety ratio
satiety ratio
eating rate, average
avg eating rate
meal duration, average light
avg light-meal dur
meal duration, average dark
avg dark-meal dur
meal size, average light
avg light-meal size
meal size, average dark
avg dark-meal size
inter-meal interval, average light
avg light-IMI
inter-meal interval, average dark
avg dark-IMI
meals, number light
light-num meals
meals, number dark
dark-num meals
satiety ratio, light
light-satiety ratio
satiety ratio, dark
dark-satiety ratio
eating rate, light
light-eating rate
eating rate, dark
dark-eating rate
food intake
food intake



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0001402hypoactivity
general reduced locomotor activity; reduced movement from one place to another or having a decreased state of activity [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0005202lethargy
mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction [ISBN:0-683-40008-8]
MMPC Search Results
MP:0005290decreased oxygen consumption
less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body [MESH:G06.535.723]
MMPC Search Results
MP:0005458increased percent body fat/body weight
more fat| relative to controls| expressed as a percentage of total body weight [MGI:cwg]
MMPC Search Results
MP:0008963increased carbon dioxide production
increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010024increased total body fat amount
greater than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0010124decreased bone mineral content
reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area [MGI:csmith]
MMPC Search Results
MP:0010378increased respiratory quotient
increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls [MGI:csmith]
MMPC Search Results
MP:0010968decreased compact bone area
reduction in the total amount of cross-sectional area of compact bone tissue [MGI:csmith]
MMPC Search Results
MP:0011939increased food intake
increase in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0011940decreased food intake
reduction in the total number of calories/food amount taken in over time when compared to the normal state [MGI:csmith]
MMPC Search Results
MP:0011945increased eating frequency
increase in the number of discrete instances of initiation of eating over time| regardless of amount eaten [MGI:csmith]
MMPC Search Results
MP:0011946decreased eating frequency
reduction in the number of discrete instances of initiation of eating over time| regardless of amount eaten [MGI:csmith]
MMPC Search Results
MP:0012344decreased gnawing activity
decreased biting or chewing on something [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results
MP:0014025decreased subchondral bone mineral content
decreased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces [MGI:csmith| PMID:20392241]
MMPC Search Results
MP:0014142increased body fat mass
increased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results
MP:0020211slow movement
decreased rate or speed of the coordinated movements executed with a purpose [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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