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Experiment

Sable Energy Balance #19683 3/21/16
Summary Data Summary
Investigator Sirvent, Pascal
Description Mice homozygous for the diabetes spontaneous mutation (Leprdb) become
identifiably obese around 3 to 4 weeks of age. Elevations of plasma insulin
begin at 10 to 14 days and of blood sugar at four to eight weeks. Affected mice
are polyphagic, polydipsic, and polyuric.

We would like to realize calorimetric chamber measurements and hyperinsulinic
clamp after 6 weeks of a special diet that we will provide. There will be 2
ifferent diets, so 2 groups of 12 mice. After 6 weeks, measurements in
calorimetric chambers and clamps have to be done.

Applicable research area(s): Diabetes, Obesity
Status Completed
Public Release 5/20/2018
Animal Age Measured In: day(s) post-natal (d)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals30
Experimental Conditions2
Catalog Items4
Curation Info (# flags)1
Phenotype Assays14
Phenotype Measurements420
Histology Images0
Publications0
Phenotypes1


Animals

Strain NameCommon NameFemalesMalesUnknown
B6.BKS(D)-Leprdb/J
0
30
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Safe - A03
Rodent diet destined for growing and breeding, pregnant and nursing animals. Wheat, maize, wheat bran, barley, extruded soybeans, soybean meal, hydrolyzed fish proteins, brewer’s yeast, calcium carbonate, pre-mixture of vitamins, pre-mixture of...
 Safe - A03VAL
Rodent diet destined for growing and breeding, pregnant and nursing animals. This diets is the same as Safe - A03 with the addition of 3% corn oil and 2.7% Valedia. Wheat, maize, wheat bran, barley, extruded soybeans, soybean meal, hydrolyzed...
Experimental Factor (Units)
Experimental Group
Mouse Diet



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