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Experiment

Metabolic measurements in Gli2 mice
Summary Data Summary
Investigator Muenke, Maximilian
Description We are using a Gli2 heterozygous knockout strain as a model of fatty liver
disease. It is our hypothesis that mutations in the Shh pathway predispose to
fatty liver in the general population. Mutant and wild-type mice were exposed to
control or high-fat diet for 12 weeks. Endpoint evaluations included weight
gain, body composition EchoMRI, liver ultrasound and ex vivo liver MRI
spectroscopy. Also blood and liver tissue were collected for metabolic and
histological examination. Preliminary Phenotype: Gli2 het mice are anatomically
and behaviorally normal to the best of our knowledge.

Gli2 het mice are anatomically and behaviorally normal to the best of our
knowledge.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/13/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals28
Experimental Conditions5
Catalog Items2
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements56
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
14
0
B6-Gli2tmMat
0
14
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor: Tissue Source

 liver
liver
Experimental Factor Values


Phenotype Assays Add / Edit


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