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Experiment

Metabolic Cage Study in Chow & HFD-fed Adiponectin-RAGE KO Mice
Summary Data Summary
Investigator Schmidt, Ann Marie
Description Homozygous RAGE null mice (C57BL/6 Ager2/2 mice backcrossed >20 generations into
C57BL/6J [The Jackson Laboratory, Bar Harbor, ME]) and their littermate
RAGEexpressing controls were used. Ay mice (B6.Cg-Ay/J) (20) were purchased from
The Jackson Laboratory and bred with homozygous RAGE null mice to generate
C57BL/6 Ay/a; Ager2/2 and littermate controls. All mice studied were male, had
free access to water, and were subjected to 12-h light/dark cycles. At 6–8 weeks
of age, mice were fed HFD with 60% of calories from lard (D12492; Research
Diets, Inc., New Brunswick, NJ) or low-fat diet (LFD) with 13% of calories from
fat (5053 PicoLab Rodent Diet 20; LabDiet, Brentwood, MO). Fat and lean masses
were measured by dual-energy X-ray absorptiometry (DEXA) scanning.

Applicable research area(s): Obesity, Metabolism
Status Completed
Public Release 6/20/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainMetadata
Data Analysis
TypeCount
Animals16
Experimental Conditions3
Catalog Items3
Curation Info (# flags)2
Phenotype Assays10
Phenotype Measurements784
Histology Images0
Publications0
Phenotypes3


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6-Agertm1Arnd/+ Tg(Adipoq-cre)1Evdr
0
16
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet 5053
PicoLab Rodent Diet 20, 21.0% protein (Calories: 24.5% protein, 13.1% Fat, 62.4% Carbohydrate)
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor: Total Time on Diet (wk)

 total time on diet
The total amount of time, in weeks, the subject spent on the particular diet.


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