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Experiment

In vivo metabolism - In vivo metabolism - Y4001 PXN1754, Y4057 PXN1754
Summary Data Summary
Investigator Enerback, Sven
Description FOXC2 plays a role in human conditions such as obesity, dyslipidemia, and type 2
diabetes. Human FOXC2 mutations are associated not only with obesity and type 2
diabetes but also with defects in lymphangiogenesis (lymphoedema-distichiasis
syndrome). Previous work showed that specific expression of FOXC2 in adipocytes
led to conversion of WAT to a ‘‘brown’’-like adipose tissue phenotype in
transgenic mice (FOXC2-TM). Adipocytes from such mice exhibit a 4-fold increase
in oxygen consumption. Thus, this is an optimal model to study how
vascularization is regulated in response not only to tissue remodeling (more
brown-like adipocytes) but also to an increased metabolic rate.

Applicable research area(s): Diabetes, Obesity, Metabolism, Cardiovascular
Status Completed
Public Release 9/18/2010
Data Collected? Data will not be collected for this catalog item
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals16
Experimental Conditions2
Catalog Items2
Curation Info (# flags)1
Phenotype Assays21
Phenotype Measurements284
Histology Images0
Publications0
Phenotypes3


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J-Tg(Foxc2)
0
7
0
C57BL/6J +/+
0
9
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 BioServ F3282
Rodent Hig Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
 LabDiet 5001
crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)
Experimental Factor (Units)
Experimental Group
Mouse Diet


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