MMPC :: Experiment

Experiment

In vivo metabolism - In vivo metabolism - Y4001 PXN1754, Y4057 PXN1754

Summary

Data Summary

Investigator	Enerback, Sven
Description	FOXC2 plays a role in human conditions such as obesity, dyslipidemia, and type 2 diabetes. Human FOXC2 mutations are associated not only with obesity and type 2 diabetes but also with defects in lymphangiogenesis (lymphoedema-distichiasis syndrome). Previous work showed that specific expression of FOXC2 in adipocytes led to conversion of WAT to a ‘‘brown’’-like adipose tissue phenotype in transgenic mice (FOXC2-TM). Adipocytes from such mice exhibit a 4-fold increase in oxygen consumption. Thus, this is an optimal model to study how vascularization is regulated in response not only to tissue remodeling (more brown-like adipocytes) but also to an increased metabolic rate. Applicable research area(s): Diabetes, Obesity, Metabolism, Cardiovascular
Status	Completed
Public Release	9/18/2010
Data Collected?	Data will not be collected for this catalog item
Animal Age	Measured In: week(s) post-natal (w)
Flags

Data Analysis

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Animals

Strain Name	Common Name	Females	Males	Unknown
C57BL/6-Tg(Fabp4-Foxc2)	C57BL/6J-Tg(Foxc2)	0	7	0
C57BL/6J ^+/+	C57BL/6J ^+/+	0	9	0

Animals/Strains

Experimental Factors

	Categorical Values
	Name / Abbreviation	Description
	Experimental Factor: Experimental Group
	Control	This animal belongs to the control group for the experiment.
	Experiment	This animal belongs to experimental group that is homozygous for gene manipulations.
	Experimental Factor: Mouse Diet
	BioServ F3282	Rodent Hig Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
	LabDiet 5001	crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)

Experimental Factor (Units)
Experimental Group
Mouse Diet

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
body mass	W rodent
glucose uptake	glucose uptake
glucose infusion rate	glucose infusion rate
fat body mass	fat body mass
lean body mass	lean body mass
glucose, basal	glucose, basal
hepatic glucose production, basal	hepatic glucose production, basal
glucose turnover, whole body	glucose turnover, whole body
glycogen/lipid synthesis, whole body	glycogen/lipid synthesis, whole body
glycolysis, whole body	glycolysis, whole body
glycogen synthesis	glycogen synthesis
glycolysis	glycolysis
glucose, clamp average	glucose, clamp average
Hepatic Glucose Production, clamp	Hepatic Glucose Production, clamp
CoA ester, C16:0	CoA ester, C16:0
CoA ester, C16:1	CoA ester, C16:1
CoA ester, C18:0	CoA ester, C18:0
CoA ester, C18:1	CoA ester, C18:1
CoA ester, C18:2	CoA ester, C18:2
CoA ester, C18:3	CoA ester, C18:3
aortic lesion complexity index	LCI

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Mammalian Phenotype (MP) Terms

MPTermID	MPTermName	Definition	Other Results
MP:0003961	decreased lean body mass	reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]	MMPC Search Results
MP:0010024	increased total body fat amount	greater than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]	MMPC Search Results
MP:0014142	increased body fat mass	increased physical bulk or volume of fat in the whole body [MGI:csmith]	MMPC Search Results

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