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Experiment

TREM-1 AN DLUPUS; Effect of Btk-B on systemic autoimmunity
Summary Data Summary
Investigator DU, YONG
Description Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR)
signaling and an important regulator of B cell development, differentiation and
signaling. It also plays a similarly important role in FcR-mediated myeloid cell
signaling. Given the multiple roles of BTK in modulating leukocyte signaling, it
is of potential interest as a therapeutic target in a number of diseases, such
as tumors, and autoimmune diseases.

We are interested in elucidating the molecular mechanisms of immune-mediated
nephritis, including lupus nephritis, Anti-glomerular basement membrane
(anti-GBM) glomerulonephritis. In this experiment, we will test the therapeutic
effect of specific BTK inhibitor, Btk-B, in these two murine lupus models.
Status Completed
Public Release 6/21/2018
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainMetadata
Data Analysis
TypeCount
Animals111
Experimental Conditions2
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements203
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
MRL/MpJ
111
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Btk-B
specific BTK inhibitor
 No Drug/Treatment
No Drug or Treatment done on these samples

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Drug Administered
Experimental Group
Experimental Factor Values


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