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Experiment

Effect of Heph (hephaestin) ablation on meal patterns
Summary Data Summary
Investigator Vulpe, Chris
Description Hephaestin is a protein expressed in many tissues in the body that are involved
in iron export from cells. Mice with a mutation in this gene have been shown to
accumulate iron in the brain and intestinal cells. We have preliminary evidence
to suggest an association with weight gain. Mutant mice also exhibit motor
defects with age.

Applicable research area(s): Obesity, Metabolism, Neurobiology
Status Completed
Public Release 6/24/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal CountExperiment Description
Data Analysis
TypeCount
Animals26
Experimental Conditions2
Catalog Items5
Curation Info (# flags)2
Phenotype Assays51
Phenotype Measurements520
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J +/+
6
7
0
Hephtm1.2Jdun
6
7
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...


Phenotype Assays Add / Edit

NameAbbreviation
body mass
W rodent
energy intake (24 hr)
energy intake (24 hr)
oxygen consumption (Light Period)
VO2-L
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
RER-L
bone mineral density
BMD
bone mineral content
BMC
bone area
bone area
fat tissue, %
% body fat
heat (Light Period)
HEAT-Light
oxygen consumption (Dark Period)
VO2-D
carbon dioxide production Light Period
VCO2-L
carbon dioxide production Dark Period
VCO2-D
respiratory exchange ratio (Dark Period)
RER-D
heat (Dark Period)
HEAT-Dark
carbon dioxide production
VCO2
heat
HEAT
oxygen consumption
VO2
respiratory exchange ratio
RQ
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
tissue area
tissue area
total tissue mass
TTM
heat (24hr)
heat - 24h
meal duration (Avg) - Active Eating Time
avg meal dur AET
meal size (Avg)
avg meal size
meals, number
num meals
inter-meal interval, average
avg IMI
meal duration (total)
total meal duration
satiety ratio
satiety ratio
eating rate, average
avg eating rate
meal duration, average light
avg light-meal dur
meal duration, average dark
avg dark-meal dur
meal size, average light
avg light-meal size
meal size, average dark
avg dark-meal size
inter-meal interval, average light
avg light-IMI
inter-meal interval, average dark
avg dark-IMI
meals, number light
light-num meals
meals, number dark
dark-num meals
satiety ratio, light
light-satiety ratio
satiety ratio, dark
dark-satiety ratio
eating rate, light
light-eating rate
eating rate, dark
dark-eating rate
food intake
food intake



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