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Experiment

Metabolic Clamp Study in Liver-Specific Insulin Receptor KO Mice
Summary Data Summary
Investigator Davis, Roger J.
Description This experiment will help clarify the role of insulin receptor in hepatocytes
under high fat diet challenge.  The results of this study will further our
understanding of insulin resistance, hepatic steatosis and diabetes.

Mice lacking hepatic expression of Insr do not gain as much weight when fed a
high-fat diet compared to control mice.

Applicable research area(s): Diabetes, Metabolism, Obesity
Status Completed
Public Release 3/22/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals20
Experimental Conditions1
Catalog Items4
Curation Info (# flags)1
Phenotype Assays14
Phenotype Measurements280
Histology Images0
Publications0
Phenotypes5


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
10
0
MIP-Cre Mapk8ip1 KO
0
4
0
Rip-MKK4/7 DKO
0
6
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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