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Experiment

Circulating adiponectin levels in B6 mice treated with letrozole
Summary Data Summary
Investigator Thackray, Varykina
Description Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype.

Pubertal (4 week old) female mice were implanted with a placebo or letrozole
pellet (50 ug/day) and treated for 5 weeks. Mice had ad lib access to food and
water. Mice were sacrificed with isoflurance and blood was collected via the
vena cava and spun down to collect serum.

Applicable research area(s): Metabolism
Status Completed
Public Release 8/4/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals31
Experimental Conditions9
Catalog Items2
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements62
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6N
31
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 SC
The drug was delivered subcutaneously.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Teklad - 7004
Rodent diet with 29% kcal fat, 51% kcal carbohydrate, 20% kcal protein

Experimental Factor: Tissue Source

 serum
serum



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