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Experiment

Effect of Maternal DDT exposure on baseline energy expenditure
Summary Data Summary
Investigator La Merrill, Michele
Description While less of a problem in the USA, exposure to the pesticide
4,4'-dichlorodiphenyltrichloroethane (DDT) due to environmental contamination
and in regions where DDT continues to be used extensively for malaria control,
or were born prior to its ban elsewhere is still a major health concern. The
goal of this study is to understand the possible contribution of DDT to
metabolic syndrome.

Female C57BL/6J mice whose mothers were treated with either Vehicle (oil) or DDT
(1.7mg/kg, po, 14 days) were assessed for baseline energy expenditure by
indirect calorimetry, body composition by DEXA, and core body temperature
measured by IP implanted temperature recorder.

Applicable research area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 8/29/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals15
Experimental Conditions2
Catalog Items1
Curation Info (# flags)2
Phenotype Assays31
Phenotype Measurements465
Histology Images0
Publications0
Phenotypes2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
15
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Experimental Group

 Mother injected with DDT
The mother of this animal was injected with DDT
 Mother injected with Oil
The mother of this animal was injected with oil

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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