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Experiment

Circulating insulin levels in B6 mice treated with letrozole (part 5)
Summary Data Summary
Investigator Thackray, Varykina
Description Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype.

Female mice with either Placebo or Letrozole pellets implants (5 weeks) were
fasted for 5 hrs starting at 8am and euthanized using isoflurance overdose.
Blood was collected via a 25G needle through the mouse aorta. Blood is tend
processed at 4C and spun down for serum. The objective of this study is to
obtain data regarding insulin and LBP levels in fasted placebo and letrozole
mice.
Status Completed
Public Release 12/4/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals18
Experimental Conditions9
Catalog Items2
Curation Info (# flags)2
Phenotype Assays1
Phenotype Measurements18
Histology Images0
Publications0
Phenotypes1


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
18
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 SC
The drug was delivered subcutaneously.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Teklad - 7004
Rodent diet with 29% kcal fat, 51% kcal carbohydrate, 20% kcal protein

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


Phenotype Assays Add / Edit


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