mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Experiment

Experiment for Order #1497
Summary Data Summary
Investigator Weinstein, Adam
Description The present proposal is for continuation of a long-standing research program
that had been directed at studying the ion exchangers mediating acid-base and
NaCI transport in the proximal tubule. As part of this program, the applicants
identified and characterized a novel anion exchanger (SLC26A6) that was named
CFEX based on its ability to mediate Cl-formate exchange. They also found that a
second related transporter, SLC26A7, is also expressed on the apical membrane of
proximal tubule cells. Their recent studies using CFEX null mice have revealed
that CFEX, by virtue of its activity as a Cl-oxalate exchanger, plays essential
roles in proximal tubule NaCI absorption and intestinal oxalate secretion. They
demonstrated that the latter process is critical to limiting net intestinal
absorption of oxalate and preventing hyperoxaluria and calcium oxalate
urolithiasis. Although the applicants plan to continue to examine the roles of
CFEX and SLC26A7 in proximal tubule NaCI transport, a major new translational
research effort will focus on the use of mouse models to elucidate the roles of
CFEX and related transporters in the integrative physiology of oxalate
homeostasis and the pathogenesis of hyperoxaluria and urolithiasis.

Applicable research area(s): Genitourinary, Metabolism
Status Completed
Public Release 5/21/2011
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainMetadataExperiment Description
Data Analysis
TypeCount
Animals30
Experimental Conditions1
Catalog Items1
Curation Info (# flags)3
Phenotype Assays1
Phenotype Measurements29
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
129/SveJ +/+
10
4
0
129S-Slc26a6-/-
6
10
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


Phenotype Assays Add / Edit


No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.