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Experiment

Hyperinsulinemic Clamp Order #1406 7/16/07
Summary Data Summary
Investigator Aird, Fraser
Description Prenatally androgenized (PA) female rodents exhibit many of the reproductive and
metabolic phenotypes of the polycystic ovary syndrome. Metabolic features
include insulin resistance, obesity, visceral adiposity, lipid imbalances and
hepatic steatosis, also found in type 2 diabetes and the metabolic syndrome. The
PA mouse model can be used to examine the role of the intrauterine environment
in developmental programming of susceptibility to these metabolic phenotypes
later in life.

Applicable research area(s): Diabetes, Polycycstic Ovary Syndrome
Status Completed
Public Release 9/16/2011
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals35
Experimental Conditions4
Catalog Items1
Curation Info (# flags)1
Phenotype Assays18
Phenotype Measurements1631
Histology Images0
Publications0
Phenotypes3


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
15
20
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Surgical Procedure

 Prenatally androgenized
Prenatally androgenized (PA) female rodents exhibit many of the reproductive and metabolic phenotypes of polycystic ovary syndrome.
 Unmanipulated
Control for surgical procedure where animal has not been manipulated
Experimental Factor Values


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