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New comment to be added:
Effect of maternal antibodies on neonatal body composition
Antibody negative (B6.Cg-Ighmtm1Cgn) and positive (B6.Cg-Ighmtm1Cgn/+) females
were crossed with C57BL6/J males. Individual genotype from the cross of female
B6.129S2-Ighmtm1Cgn/+ and C57BL6/J males are unknown and strain defined as
B6;B6.129S2-Ighmtm1Cgn . However, mice contain at least one functional copy of
the Imgh gene and are either B6.129S2-Ighmtm1Cgn/+ or wild type.Pups from cross
were not genotyped so genotype of offspring from first cross are all het for KO
and named B6.129S2-Ighmtm1Cgn/+. Body composition of resulting pup were assessed
using DEXA at 26 days of age.
It has been found that compared to control offspring, pups lacking maternal
antibodies exhibit a 'growth faltering' phenotype around d18-d28 of age. The PI
is interested in characterizing the mechanisms that lead to this lag in weight
gain during this period. As a first step, the PI would like to characterize the
physiological differences between these maternal antibody sufficient and
deficient pups. For example, do mice lacking maternal antibodies exhibit
differences in adipose tissue deposition, muscle growth and bone growth? Or is
it just a subset of these tissues that is affected? Based on some preliminary
data, it is hypothesize that adipose tissue deposition is altered in pups
lacking maternal antibodies, whereas muscle (& bone) formation is normal.
Applicable research area(s): Metabolism
day(s) post-natal (d)
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Name / Abbreviation
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
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fat body mass
fat body mass
lean body mass
lean body mass
bone mineral density
bone mineral content
fat tissue, %
% body fat
total tissue mass
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