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pathophysiological effects of arsenic on the metabolism and energy balance of
adult mice
Summary Data Summary
Investigator La Merrill, Michele
Description Arsenic is an environmental toxin that affects many aspects of mammalian
physiology. The exact mechanisms underlying such arsenic effects are mostly
unclear. The aim of this project is to assess the pathophysiological effects of
arsenic on the metabolism and energy balance of adult mice, specifically
assessing the effects on beiging and brown fat activation. To accomplish this
control or Arsenic (300ppb) treated mice will undergo indirect calorimetry at
thermal neutral (30°C), standard vivarium temperature (23°C), and mild to
moderate cold stress (12 and 4°C). Core temperatures will be taken (with a
rectal probe) and body composition assessed by DEXA.

Applicable research area(s): Diabetes, Metabolism
Status Completed
Public Release 9/11/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
Experimental Conditions7
Catalog Items3
Curation Info (# flags)1
Phenotype Assays31
Phenotype Measurements2480
Histology Images0

Strain NameCommon NameFemalesMalesUnknown

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

A metallic element that forms a number of poisonous compounds

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

parts per billion

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

Also known as D10001. Protein 20.3g 20.8kcal, Carbohydrate 66.0g 67.7kcal, Fat 5.0g 11.5kcal Ingredients: Casein 200g, DL-Methionine 3g, Corn Starch 150g, Sucrose 500g, Cellulose (BW200) 50g, Corn Oil 50g, Mineral Mix (S10001) 35g, Vitamin Mix...

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