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Experiment

Assessment of energy expenditure of dominant negative SNAP25 mutant mice.
Summary Data Summary
Investigator Kraemer, Fredric
Description Mice expressing the dominant negative mutation in SNAP-25 demonstrate are
smaller with reduced adipose depots compared with wild-type control mice. Mutant
mice also have lower fasting glucose levels and improved glucose tolerance on a
chow diet compared with wild-type control mice. However, it is unknown if this
is a result of altered whole body energy expenditure, food intake or activity.
After 1 week acclimation to vivarium, mice undergo indirect respiratory
calorimetry and DEXA to assess energy expenditure and body composition.
Status Completed
Public Release 3/26/2022
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals8
Experimental Conditions1
Catalog Items1
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements248
Histology Images0
Publications0
Phenotypes8


Animals
Strain NameCommon NameFemalesMalesUnknown
C3H/HeH
0
4
0
C3.Cg-Snap25Bdr
0
4
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


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