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New comment to be added:
Influence of NNAT KO on energy expenditure at various environmental temperatures
in female mice
To determine whether inactivation of NNAT alters energy expenditure assessed at
several different temperatures (female mice are used).
Neuronatin (encoded by the gene NNAT) is a proteolipid that may be involved in
the regulation of ion channels during brain development. This protein may also
play a role in forming and maintaining the structure of the nervous system.
Previous studies by Dr Yoon’s group has shown that NNAT KO mice have an increase
in WAT, decrease in BAT compared to WT mice. In addition, they are better able
to sustain core body temperature during a cold challenge. The purpose of the
first study is to determine effect of NNAT KO on energy expenditure, food intake
and activity at thermal neutral (30°C), standard vivarium temperature (22°C),
and cold challenge (10°C). This will be assessed in female mice.
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Environmental Temperature (°C)
The temperature of the environment when the measurement was taken.
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Environmental Temperature (°C) (°C)
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oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
bone mineral density
bone mineral content
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
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