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Experiment

Influence of NNAT KO on energy expenditure at various environmental temperatures
in female mice
Summary Data Summary
Investigator Yoon, John
Description To determine whether inactivation of NNAT alters energy expenditure assessed at
several different temperatures (female mice are used).
Neuronatin (encoded by the gene NNAT) is a proteolipid that may be involved in
the regulation of ion channels during brain development. This protein may also
play a role in forming and maintaining the structure of the nervous system.
Previous studies by Dr Yoon’s group has shown that NNAT KO mice have an increase
in WAT, decrease in BAT compared to WT mice. In addition, they are better able
to sustain core body temperature during a cold challenge. The purpose of the
first study is to determine effect of NNAT KO on energy expenditure, food intake
and activity at thermal neutral (30°C), standard vivarium temperature (22°C),
and cold challenge (10°C). This will be assessed in female mice.
Status Completed
Public Release 3/21/2022
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals18
Experimental Conditions2
Catalog Items3
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements1674
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6N +/+
9
0
0
NNAT -/-
9
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.


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