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Experiment

NMR 3/29/2018
Summary Data Summary
Investigator Faulkner, Latrice
Description This strain is used to identify neuronal targets for the treatment of obesity.
Status Completed
Public Release 3/21/2021
Animal Age Measured In: week(s) post-natal (w)
Flags No data
Data Analysis
TypeCount
Animals0
Experimental Conditions2
Catalog Items1
Curation Info (# flags)1
Phenotype Assays4
Phenotype Measurements0
Histology Images0
Publications0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
 Control-Het
This animal belongs to the control group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Virus Injected

 lacZ Adenovirus
Adenovirus with lacZ cassette
 Lpcat3 shRNA Adenovirus
Adenovirus that expresses an shRNA for lysophosphatidylcholine acyltransferase 3 (Lpcat3)
 Ad-shNOX4
Adenovirus that expresses an shRNA for NOX4
 Ad-shGFP
Adenovirus that expresses an shRNA for GFP
 Vehicle
Injection of vehicle without virus. Negative control.
 AAV-GFP
Adeno associated virus with over expressing green fluorescent protein (GFP)
 AAV-C5
Adeno associated virus with over expression of Human Complement C5
 AAV-B186-Vegfb
Adeno Associated Virus B186 over expresses Vegfb.
 AAV-Control
Empty Adeno Associate Virus control.
 Adenovirus IRE1a K599A
An Adenovirus expressing the K599A mutant of the IRE1a gene.
 Adenovirus 3xFLAG Sirt6
Adenoviruses were produced with the pAd-Track/pAd-Easy system. 3xFLAG Sirt6 adenoviruses were subcloned from pCMV7.1-3xFLAG constructs. Adenoviruses containing shRNAs were subcloned from pLKO.1 vectors with the U6 promoter into the...
 AAV-March1
Adeno associated virus with over expression of March1
 AAV8-Cre-GFP
AAV serotype 8 virus expresses Cre Recombinase and eGFP marker
 AAV8-Cre
AAV serotype 8 virus expresses Cre Recombinase
 AAV8-Lrh1
AAV serotype 8 virus expresses Lrh1
 AAV-PCSK9
Adeno associated virus with over expressing proprotein convertase subtilisin/kexin type 9
 AAV-DIO-mcherry
Control AAV virus is cre dependent for the expression of a fluorophore, indicating the cre positive neurons are infected by the virus.
 AAV-DIO-GFP:TetTox
AAV-TetTox is to cre-dependently express not only a fluorophore but also a protein called TetTox, which will block the virus infected cre positive neurons from receiving neurotransmitters/hormones/peptides from connected neurons.
 AAV-pCAG-Atg5
AAV9 encoding an over expression cassette for autophagy related 5 gene (Atg5).
 AAV-pCAG-Cisd2
AAV9 encoding an over expression cassette for CDGSH iron sulfur domain 2 (Cisd2).
 AAV-pCB7-mAFP
AAV9 encoding an over expression cassette for Mouse alphafetoprotein (mAFP).
 Coxsackie B4
Coxsackie B4 has a cell tropism for natural killer cells and pancreatic islet cells
 None
No virus was injected.
 MCMV
Mouse cytomegalovirus
 AAV8-miR375
miR375 treatment mediated via virus
 AAV8-CBG
AAV serotype 8 virus expresses corticosteroid-binding globulin (SERPINA6)
 AAV8
AAV serotype 8 virus
 AAV Klotho
An adeno-associated virus (AAV) carrying mouse klotho full-length cDNA.
Experimental Factor (Units)
Experimental Group
Virus Injected



No documents found.

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