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Experiment

Circulating insulin, lipid and CRP levels in B6 mice treated with letrozole and
fed fiber diet
Summary Data Summary
Investigator Thackray, Varykina
Description Letrozole treatment of pubertal female mice results in hallmarks of PCOS
including elevated androgens, anovulation, polycystic ovaries and a metabolic
phenotype.
Status Completed
Public Release 12/10/2022
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountMouse Diet
Data Analysis
TypeCount
Animals39
Experimental Conditions9
Catalog Items4
Curation Info (# flags)3
Phenotype Assays5
Phenotype Measurements195
Histology Images0
Publications0
Phenotypes2


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6N
39
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 SC
The drug was delivered subcutaneously.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Teklad - 200354
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated, with 5% Benefiber
 Teklad-130852
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


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