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Experiment

Hyperinsulinemic clamp order #30515 Jan 2021
Summary Data Summary
Investigator Li, Tiangang
Description Western diet feeding for 8 weeks to induce hyperglycemia. Mice were injected
with Vehicle or TAS4464 subcutaneously) at 5 pm on day 1 and 9 am on day 2.
Insulin clamp were carried out on day 2 at ~12-1pm (~4 h after the second
injection, 5hr fasted).
Hyperinsulinemic-euglycemic clamp on 5-hour fasted mice.
Status Completed
Public Release 9/14/2023
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal Count
Data Analysis
TypeCount
Animals17
Experimental Conditions6
Catalog Items1
Curation Info (# flags)2
Phenotype Assays16
Phenotype Measurements4165
Histology Images0
Publications0
Phenotypes7


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
17
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Saline
Saline
 TAS4464
A highly potent and selective inhibitor of NEDD8 activating enzyme (NAE).

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
Experimental Factor Values


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