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Experiment

Cobas Order # 2371
Summary Data Summary
Investigator Raycroft, Maurice
Description Background: Scavenger receptor A (SR-A) is implicated in the development of
autoimmunity.

Results: Deficiency of SR-A, anti-SR-A antibody, and small molecule inhibitors
(SMIs) block antigen processing.

Conclusion: Two SMIs (sennoside B and tannic acid) that reduce antigen transfer
and T cell immunity were identified.

Significance: SR-A-mediated antigen trafficking is blocked by SMIs, leading to
reduced T cell responses.

Applicable research area(s): Diabetes, Human disease
Status Completed
Public Release 12/12/2013
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainMetadataAnimal CountExperiment Description
Data Analysis
TypeCount
Animals30
Experimental Conditions1
Catalog Items1
Curation Info (# flags)4
Phenotype Assays1
Phenotype Measurements30
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
10
0
0
MRL/MpJ
20
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


Phenotype Assays Add / Edit


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