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Experiment

2021-08-01 Olson - Ian 14 Mice NMR
Summary Data Summary
Investigator Olson, David
Description We injected NOS1-Cre mice with 4Di to investigate acute and chronic inhibition
of NOS1 neurons in the PVH
Status Completed
Public Release 2/3/2024
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagExperiment / ControlNo dataNeed Conditions
Data Analysis
TypeCount
Animals14
Experimental Conditions5
Catalog Items1
Curation Info (# flags)3
Phenotype Assays7
Phenotype Measurements189
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
B6.129-Nos1tm1(cre)Mgmj/J
14
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Clozapine N-oxide
Inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its
 Saline
Saline

Experimental Factor: Experimental Group

 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...

Experimental Factor: Second Drug Administered

 Clozapine N-oxide
The second drug that was administered during the study.
 Saline
The second drug that was administered during the study.
Experimental Factor Values


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