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Experiment

2022-06-08 Feldman-Faye-10 mice NMR
Summary Data Summary
Investigator Mendelson, Faye
Description Peripheral neuropathy is a common complication of prediabetes. In murine models
of prediabetes, the progression of peripheral neuropathy correlates with
dyslipidemia. C57BL6/J mice fed a 45% saturated fatty acid-rich high fat diet
(HFD-SFA) robustly model peripheral neuropathy in prediabetes because they
develop both metabolic dysfunction including gain weight, develop dyslipidemia,
and impaired glucose tolerance that correlate with the development of peripheral
neuropathy. Mice switched from HFD-SFA to a high fat diet rich in
monounsaturated fatty acids (HFD-MUFA) retain metabolic dysfunction but have
restored nerve function. In this study, we sought to determine the effect of
supplementing the 45% HFD-SFA with a triglyceride composed of 3 acyl chains of
MUFA oleic acid on metabolic function and nerve function. The goal of this
EchoMRI experiment is to determine the effect of triolein supplementation on
body composition.
Status Completed
Public Release 6/21/2024
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagExperiment / Control
Data Analysis
TypeCount
Animals10
Experimental Conditions2
Catalog Items1
Curation Info (# flags)1
Phenotype Assays4
Phenotype Measurements40
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
10
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 45% HFD-SFA
45% saturated fatty acid-rich high fat diet (HFD-SFA) with 15% triolein & 10% lard
Experimental Factor (Units)
Experimental Group
Mouse Diet
Experimental Factor Values


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