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Experiment

Metabolic Study in FBXO31 KO Mice
Summary Data Summary
Investigator Green, Michael
Description The tumor suppressor protein p53 plays a critical role in protecting humans from
cancer. In response to cellular stresses, such as DNA damage, p53 levels
increase and induce a variety of protective biological responses. In unstressed
cells, p53 is maintained at a low level by MDM2, a protein that interacts with
p53 and promotes its degradation. Following DNA damage, MDM2 is degraded
rapidly, resulting in increased p53 levels. Because of the essential role of
MDM2 in modulating p53 function, it is critical to understand how MDM2 levels
are regulated. Here we show that, following DNA damage, the F-box protein
FBXO31, a potential tumor suppressor, is responsible for promoting MDM2
degradation and therefore is essential for the increase in p53 levels.

Applicable research area(s): Metabolism
Status Completed
Public Release 9/25/2015
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainAnimal CountExperiment Description
Data Analysis
TypeCount
Animals15
Experimental Conditions1
Catalog Items3
Curation Info (# flags)3
Phenotype Assays12
Phenotype Measurements180
Histology Images0
Publications0
Phenotypes6


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
7
0
FBXO31 KO
0
8
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.



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