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Experiment

Investigation of systemic loss of bone mass following bone fracture in young
mice- DEXA analysis with baseline and 3 timepoints post-fracture
Summary Data Summary
Investigator Christiansen, Blaine
Description Using Wild type C57BL/6 mice, the goal of the research is to investigate
systemic loss of bone mas following bone fracture in mice. Using DEXA, bone loss
and activity levels will be monitored in control and bone-fractured mice.
Systemic bone loss and voluntary activity levels in mice will be examined at
multiple time points following femur fracture.

The hypothesis is that bone fracture will initiate a systemic adaptive response
including decreased activity levels, which will result in a systemic loss of
bone mass, contributing to a general decrease in skeletal strength.
Status Completed
Public Release 6/18/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainExperiment Description
Data Analysis
TypeCount
Animals24
Experimental Conditions3
Catalog Items1
Curation Info (# flags)2
Phenotype Assays7
Phenotype Measurements1064
Histology Images0
Publications0
Documents5
Phenotypes8


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
24
0
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Surgical Procedure

 anesthesia control
The anesthesia control animals.
 femur fracture
The femur is experimentally fractured.
 Sham
Control Sham Procedure
 Unmanipulated
Control for surgical procedure where animal has not been manipulated



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0000063decreased bone mineral density
reduction in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0003961decreased lean body mass
reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0010025decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0013616decreased volumetric bone mineral density
reduction in the mineral mass per unit volume of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3)| with results generated from Quantitative computed tomography (QCT) and other tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0013618decreased areal bone mineral density
reduction of the mineral mass per unit area of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2)| with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0014143decreased body fat mass
decreased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results
MP:0020010decreased bone mineral density of femur
reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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