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Meeting Info
Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery

Meeting Type External
Start Date 3/16/2026
End Date 3/19/2026
Location Breckenridge, CO
Url External Info
Purpose The islets of Langerhans are critical for glucose homeostasis but fail in
diabetes, accompanied by autoimmune destruction of beta-cells in type 1 diabetes
and increased insulin demand and beta-cell exhaustion in type 2 diabetes. During
the last decade, there have been major advances not only in the molecular
understanding of beta-cell stress, unfolded protein response, dedifferentiation,
aging and failure, but also in counteracting mechanisms, such as beta-cell
maturation, compensation, redifferentiation, autophagy and recovery. This
meeting will address unresolved gaps in how these mechanisms intersect and how
to shift fundamental insights into possible approaches and therapies to reverse
diabetes. In parallel, this meeting will address how we can combine primary
islets, differentiated stem cells or regenerative mechanisms with immune-evasive
strategies for beta-cell replacement in type 1 diabetes.
Agenda (pdf) None Submitted
Minutes (pdf) None Submitted
Front Page? No

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