mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
GDF15 Knockout Does Not Substantially Impact Perinatal Body Weight or Neonatal
Outcomes in Mice.
Authors Mulcahy MC, El Habbal N, Redd JR, Sun H, Gregg BE, Bridges D
Submitted By Submitted Externally on 2/7/2025
Status Published
Journal Endocrinology
Year 2024
Date Published 10/1/2024
Volume : Pages 165 : Not Specified
PubMed Reference 39445824
Abstract Growth differentiation factor-15 (GDF15) increases in circulation during
pregnancy and has been implicated in food intake, weight loss, complications of
pregnancy, and metabolic illness. We used a Gdf15 knockout mouse model
(Gdf15-/-) to assess the role of GDF15 in body weight regulation and food intake
during pregnancy. We found that Gdf15-/- dams consumed a similar amount of food
and gained comparable weight during the course of pregnancy compared with
Gdf15+/+ dams. Insulin sensitivity on gestational day 16.5 was also similar
between genotypes. In the postnatal period, litter size and survival rates were
similar between genotypes. There was a modest reduction in birth weight of
Gdf15-/- pups, but this difference was no longer evident from postnatal day 3.5
to 14.5. We observed no detectable differences in milk volume production or milk
fat percentage. These data suggest that GDF15 is dispensable for changes in food
intake, and body weight as well as insulin sensitivity during pregnancy in a
mouse model.




Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.