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Publication
Distributed Control of Muscle Glucose Uptake: A Tribute to the Late Dr. David H.
Wasserman by Revisiting a 2004 Diabetes Classic by Fueger et al.
Authors Ayala JE
Submitted By Julio Ayala on 12/12/2025
Status Published
Journal Diabetes
Year 2025
Date Published
Volume : Pages 74 : 1889 - 1891
PubMed Reference 41115415
Abstract The control of muscle glucose uptake (MGU) is distributed across delivery,
transport, and phosphorylation of glucose. These steps have been defined as
control points of MGU in vivo due to the application of isotopic tracer
techniques to transgenic mouse models. Using these techniques in a classic study
published in Diabetes, Fueger et al. demonstrated that overexpression in
skeletal muscle of hexokinase II (HKII), the enzyme responsible for
intracellular glucose phosphorylation, enhanced MGU in insulin-sensitive but not
in insulin-resistant mice. Conversely, HKII overexpression enhanced MGU in
insulin-resistant mice in response to exercise. Since exercise reduces barriers
of glucose delivery and transport, this suggested that these two processes
contribute to the dysregulation of MGU in insulin-resistant states. These
fundamental findings have spurred subsequent studies highlighting the
contribution of glucose delivery and transport to the regulation of MGU in
health and disease.




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