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Publication
Prolonged Semaglutide Treatment Reveals Stage-Dependent Changes to Feeding
Behavior and Metabolic Adaptations in Male Mice.
Authors Shah H, Ayala JE
Submitted By Submitted Externally on 1/30/2026
Status Published
Journal Diabetes
Year 2026
Date Published 1/20/2026
Volume : Pages 75 : 288 - 300
PubMed Reference 41329075
Abstract Although many studies have demonstrated acute behavioral and metabolic effects
of glucagon-like peptide 1 receptor (GLP-1R) agonists, few have assessed
long-term effects of these drugs on these phenotypes. We assessed changes in
various behavioral and metabolic phenotypes throughout a 21-day treatment
regimen with semaglutide and posttreatment. Weight loss in response to prolonged
semaglutide treatment can be divided into distinct phases, and each phase is
characterized by different effects on food intake, meal patterns, energy
expenditure, and substrate oxidation. Our findings suggest that differences in
behavioral changes and/or metabolic adaptations may underlie the degree of
weight loss responsiveness to GLP-1R agonists.




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